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Acta Histochem. 2014 Jan;116(1):61-9. doi: 10.1016/j.acthis.2013.05.006. Epub 2013 Jul 1.

Effects of dietary extra-virgin olive oil on oxidative stress resulting from exhaustive exercise in rat skeletal muscle: a morphological study.

Author information

  • 1Department of Bio-Medical Sciences, Human Anatomy and Histology Division, University of Catania, Italy. Electronic address: g.musumeci@unict.it.
  • 2Department of Medical and Pediatric Sciences, University of Catania, Italy.
  • 3Department of Bio-Medical Sciences, Human Anatomy and Histology Division, University of Catania, Italy.

Abstract

Physical exercise induces oxidative stress through production of reactive oxygen species and can cause damage to muscle tissue. Oxidative stress, resulting from exhaustive exercise is high and improvement of antioxidant defenses of the body may ameliorate damage caused by free radicals. Extra-virgin olive oil is widely considered to possess anti-oxidative properties. The aim of this study was to determine if extra-virgin olive oil improved the adaptive responses in conditions of oxidative stress. Twenty-four 12-week-old male Sprague-Dawley rats were divided in three groups: (1) rats fed with standard chow and not subjected to physical exercise; (2) rats fed with standard chow and subjected to exhaustive exercise; (3) rats fed with a diet rich in oleic acid, the major component of extra-virgin olive oil, and subjected to exhaustive exercise. Exhaustive exercise consisted of forced running in a five-lane 10° inclined treadmill at a speed of 30 m/min for 70-75 min. We studied some biomarkers of oxidative stress and of antioxidant defenses, histology and ultrastructure of the Quadriceps femoris muscle (Rectus femoris). We observed that, in rats of group 3, parameters indicating oxidative stress such as hydroperoxides and thiobarbituric acid-reactive substances decreased, parameters indicating antioxidant defenses of the body such as non-enzymatic antioxidant capacity and Hsp70 expression increased, and R. femoris muscle did not show histological and ultrastructural alterations. Results of this study support the view that extra-virgin olive oil can improve the adaptive response of the body in conditions of oxidative stress.

KEYWORDS:

Extra-virgin olive oil; Morphology; Oleic acid; Oxidative stress; Rats; Skeletal muscle

PMID:
23810034
DOI:
10.1016/j.acthis.2013.05.006
[PubMed - indexed for MEDLINE]
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