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Fertil Steril. 2013 Oct;100(4):1039-43. doi: 10.1016/j.fertnstert.2013.05.042. Epub 2013 Jun 27.

Age at menarche: a predictor of diminished ovarian function?

Author information

1
Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria; Center for Human Reproduction and Foundation for Reproductive Medicine, New York, New York. Electronic address: andrea.weghofer@meduniwien.ac.at.

Abstract

OBJECTIVE:

To investigate whether age at menarche is associated with functional ovarian reserve (FOR) later in life.

DESIGN:

Retrospective cohort study.

SETTING:

Fertility center.

PATIENT(S):

Five hundred and two infertile women.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Levels of menarcheal age, antimüllerian hormone (AMH), follicle-stimulating hormone (FSH), and functional ovarian reserve.

RESULT(S):

The mean age of the patients was 38.9 ± 4.9 years, and their mean level of AMH was 1.4 ± 2.0 ng/mL and of FSH was 10.7 ± 6.1 mIU/mL. Their current age-specific diminished functional ovarian reserve (DFOR) was statistically significantly associated with early menarche, defined as age <13 years. Logistic regression analysis, adjusting for race, affirmed the higher likelihood of early age at menarche in infertile patients with DFOR. When women with DFOR were grouped into quartiles, early menarche (<25th percentile) was associated with statistically significantly higher DFOR risk than late menarche (>75th percentile).

CONCLUSION(S):

This study demonstrates a statistically significant impact of age at menarche on DFOR risk later in life among infertile women. The occurrence of menarche may relate to follicular pool size and/or speed of follicle recruitment, which in turn is predictive of occurrence of DFOR later in life.

KEYWORDS:

Antimüllerian hormone (AMH); diminished functional ovarian reserve; follicle-stimulating hormone (FSH); menarche; ovarian function

[Indexed for MEDLINE]

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