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Nutr Hosp. 2013 Jan-Feb;28(1):232-7. doi: 10.3305/nh.2013.28.1.6165.

High-protein diets and renal status in rats.

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1
Department of Physiology, School of Pharmacy, Faculty of Sport Sciences and Institute of Nutrition and Food Technology, University of Granada, Spain. virginiaparicio@ugr.es

Abstract

in English, Spanish

INTRODUCTION:

High-protein (HP) diets might affect renal status. We aimed to examine the effects of a HP diet on plasma, urinary and morphological renal parameters in rats.

MATERIAL AND METHODS:

Twenty Wistar rats were randomly distributed in 2 experimental groups with HP or normal-protein (NP) diets over 12 weeks.

RESULTS AND DISCUSSION:

Final body weight was a 10%lower in the HP group (p < 0.05) whereas we have not observed differences on food intake, carcass weight and muscle ashes content. No significant clear differences were observed on plasma parameters, whereas urinary citrate was an 88% lower in the HP group (p = 0.001) and urinary pH a 15% more acidic (p < 0.001). Kidney wet mass was ~22 heavier in the HP group (p < 0.001). Renal mesangium area was a 32% higher in the HP group (p < 0.01). Glomerular 1 and 2 were also ~30 higher in the HP diet (p < 0.01 and p < 0.05, respectively) and glomerular area a 13% higher (p < 0.01).

CONCLUSION:

High-protein diet promoted a worse renal profile, especially on urinary and morphological markers, which could increase the risk for developing renal diseases in the long time.

PMID:
23808456
DOI:
10.3305/nh.2013.28.1.6165
[Indexed for MEDLINE]
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