Nepheliosyne B, a new polyacetylenic acid from the new caledonian marine sponge Niphates sp

Mar Drugs. 2013 Jun 27;11(7):2282-92. doi: 10.3390/md11072282.

Abstract

A new C47 polyoxygenated acetylenic acid, nepheliosyne B (2), along with the previously described nepheliosyne A (1), have been isolated from the New Caledonian marine sponge Niphates sp. Their structures have been elucidated on the basis of extensive spectroscopic analyses. These metabolites exhibited a moderate cytotoxicity against K562, U266, SKM1, and Kasumi cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry
  • Alkynes / pharmacology
  • Animals
  • Biological Factors / chemistry*
  • Biological Factors / pharmacology*
  • Cell Line, Tumor
  • Fatty Acids, Unsaturated / chemistry
  • Fatty Acids, Unsaturated / pharmacology
  • Humans
  • K562 Cells
  • Molecular Structure
  • Polyynes / chemistry*
  • Polyynes / pharmacology*
  • Porifera / chemistry*

Substances

  • Alkynes
  • Biological Factors
  • Fatty Acids, Unsaturated
  • nepheliosyne A
  • Polyynes