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AIDS. 2013 Jul 17;27(11):1829-32. doi: 10.1097/QAD.0b013e328363089f.

GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals.

Author information

1
Research and Medical Services, Iowa City VA Medical Center, Iowa City, IA 52242, USA. jack-stapleton@uiowa.edu

Abstract

GB virus C (GBV-C), a pan-lymphotropic flavivirus capable of persistent infection, is associated with prolonged survival and reduced T-cell activation in HIV-infected patients. GBV-C was associated with reduced CD56brt/CD16- natural killer cell and monocyte activation, and a trend toward reduced B-cell activation by measuring cell surface activation markers or HIV entry coreceptors. The GBV-C association was independent of HIV viral load. Thus, GBV-C may influence non-T-cell immune activation in individuals with HIV infection.

PMID:
23807277
PMCID:
PMC4539006
DOI:
10.1097/QAD.0b013e328363089f
[Indexed for MEDLINE]
Free PMC Article

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