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Am J Geriatr Psychiatry. 2014 Jul;22(7):735-40. doi: 10.1016/j.jagp.2013.02.002. Epub 2013 Jun 25.

Building a new paradigm for the early recognition of behavioral variant frontotemporal dementia: Late Onset Frontal Lobe Syndrome study.

Author information

1
Alzheimer Centre and Department of Neurology, VU University Medical Centre, Amsterdam, the Netherlands. Electronic address: w.krudop@vumc.nl.
2
Department of Old Age Psychiatry, GGZInGeest, Amsterdam, the Netherlands.
3
Alzheimer Centre and Department of Neurology, VU University Medical Centre, Amsterdam, the Netherlands.
4
Department of Radiology, VU University Medical Centre, Amsterdam, the Netherlands.
5
Department of Nuclear Medicine & PET Research, VU University Medical Centre, Amsterdam, the Netherlands.
6
Neurological Laboratory, Department of Clinical Chemistry, VU University Medical Centre, Amsterdam, the Netherlands.

Abstract

OBJECTIVE:

To describe the aims and design of the ongoing Late Onset Frontal Lobe Syndrome study (LOF study), a study on the spectrum of neurodegenerative and psychiatric etiologies causing behavioral changes in later life, and on the role of magnetic resonance imaging (MRI), [(18)F]-fluorodeoxyglucose-positron emission tomography (FDG-PET), and cerebrospinal fluid (CSF) biomarkers in predicting and identifying the different underlying pathologies with a special focus on the behavioral variant of frontotemporal dementia.

METHODS:

The LOF study is an observational cross-sectional and prospective follow-up study. Patients aged 45-75 years with a frontal behavioral change consisting of apathy, disinhibition, or compulsive/stereotypical behavior were included (April 2011-2013). Patients underwent a multidisciplinary assessment by a neurologist and psychiatrist and MRI, CSF, and PET measurements at inclusion and after 2 years of follow-up.

RESULTS:

The diagnostic added value of MRI, PET, and CSF results and their predictive value will be measured after 2 years of follow-up.

CONCLUSION:

This is the first large-scale prospective follow-up study of patients with late-onset behavioral disorders.

KEYWORDS:

behavioral disorders; bvFTD; early diagnosis; psychiatry

PMID:
23806681
DOI:
10.1016/j.jagp.2013.02.002
[Indexed for MEDLINE]
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