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Dev Cell. 2013 Jun 24;25(6):547-8. doi: 10.1016/j.devcel.2013.06.002.

Oct4: the final frontier, differentiation defining pluripotency.

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1
MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, 5 Little France Drive, University of Edinburgh, Edinburgh EH16 4UU, UK.

Abstract

The transcription factor OCT4 is a cornerstone of pluripotency, and yet OCT4 has also been associated with differentiation in a number of contexts. Reporting in this issue of Developmental Cell, Frum et al. (2013) show that OCT4's major early activity in the blastocyst is to support primitive endoderm differentiation.

PMID:
23806612
DOI:
10.1016/j.devcel.2013.06.002
[Indexed for MEDLINE]
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