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Virology. 2013 Sep;444(1-2):119-23. doi: 10.1016/j.virol.2013.05.041. Epub 2013 Jun 24.

Adenoviruses isolated from wild gorillas are closely related to human species C viruses.

Author information

1
GenVec, Inc., 65W. Watkins Mill Rd, Gaithersburg, MD 20878, USA.

Abstract

We have isolated and cultured three distinct adenoviruses from wild gorillas. Phylogenetic analysis grouped the viruses with human adenovirus species C based on DNA polymerase, hexon, and E4ORF6 genes. The three wild gorilla adenoviruses clustered with the other species C captive gorilla adenoviruses, forming a branch separate from human and chimpanzee/bonobo adenoviruses. Animal sera to the three newly isolated viruses did not cross-neutralize, demonstrating serological distinctiveness. The human adenovirus 5 fiber knob blocked infection, suggesting use of the Coxsackie and Adenovirus Receptor. These viruses may provide viral vectors with properties distinct from chimpanzee adenovirus and human adenovirus vectors.

KEYWORDS:

Adenovirus; Evolution; Gorilla; Non-human primate; Viral vectors

PMID:
23806387
DOI:
10.1016/j.virol.2013.05.041
[Indexed for MEDLINE]
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