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Wei Sheng Yan Jiu. 2013 May;42(3):415-8, 423.

[Effects of CdTe QDs on chromosome aberration of CHL cells in vitro].

[Article in Chinese]

Author information

1
Institute for Ocuupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing, China. guangyunxie@163.com

Abstract

OBJECTIVE:

To observed the chromosome oberration of CHL cells induced by CdTe QDs.

METHODS:

The chromosome oberration test of Chinese hamster lung (CHL) cell was conducted in CdTe QDs at the concentrations of 1.6, 3.2, 6.3, 12.6 and 25.2 microl/ml, under the metabolic (+S9) and non-metabolic (-S9) activation systems.

RESULTS:

The chromosome oberration rate of 12.6 and 25.2 microl/ml CdTe QDs groups were significantly higher than the control groups (P<0.01) Under the condition of metabolic activation. Main types of chromosomal aberrations was broken, fragmented and exchange.

CONCLUSION:

It was suggested that CdTe QDs could induce the effects of chromosome oberration under the metabolic activation systems (+S9).

PMID:
23805517
[Indexed for MEDLINE]

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