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J Int Med Res. 2013 Aug;41(4):956-63. doi: 10.1177/0300060513490087. Epub 2013 Jun 26.

Two nonsynonymous polymorphisms (F31I and V57I) of the STK15 gene and breast cancer risk: a meta-analysis based on 5966 cases and 7609 controls.

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1
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Abstract

OBJECTIVES:

This meta-analysis examined the relationship between two nonsynonymous polymorphisms (F31I and V57I) of the aurora kinase A (STK15) gene and breast cancer risk.

METHODS:

A systematic search of the PubMed® and EMBASE™ databases was undertaken to identify case-control studies that investigated the relationship between STK15 gene polymorphisms and breast cancer risk.

RESULTS:

This meta-analysis included seven case-control studies (5966 breast cancer cases; 7609 controls). Combined results, based on all seven studies, showed that breast cancer cases had a significantly higher frequency of the 31 Ile/Ile genotype. In a subgroup analysis by race, breast cancer cases had a significantly higher frequency of the 31 Ile/Ile genotype in Asians and Caucasians. Combined results, based on four studies, suggested that the STK15 V57I gene polymorphism was unlikely to be associated with breast cancer risk in either Asians or Caucasians.

CONCLUSIONS:

The present meta-analysis suggests that the STK15 F31I polymorphism is a strong predisposing risk factor for breast cancer, but no significant association existed between the STK15 V57I polymorphism and the risk of breast cancer.

KEYWORDS:

Aurora kinase A (STK15) gene; breast cancer; gene polymorphism; meta-analysis

PMID:
23803310
DOI:
10.1177/0300060513490087
[Indexed for MEDLINE]
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