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Asian Pac J Cancer Prev. 2013;14(5):2699-701.

Oncogenesis and the clinical significance of K-ras in pancreatic adenocarcinoma.

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Department of General Surgery, Three Gorges Medical College, Chongqing, China.


The RAS family genes encode small GTP-binding cytoplasmic proteins. Activated KRAS engages multiple effector pathways, notably the RAF-mitogen-activated protein kinase, phosphoinositide-3-kinase (PI3K) and RalGDS pathways. In the clinical field, K-ras oncogene activation is frequently found in human cancers and thus may serve as a potential diagnostic marker for cancer cells in circulation. This mini-review aims to summarise information on Ras-induced oncogenesis and the clinical significance of K-ras.

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