Format

Send to

Choose Destination
Aging Cell. 2013 Dec;12(6):943-9. doi: 10.1111/acel.12126. Epub 2013 Jul 17.

The influence of skeletal muscle on systemic aging and lifespan.

Author information

1
Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA; Division of Developmental Biology, Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

Abstract

Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the development of several age-related diseases such as metabolic syndrome, cancer, Alzheimer's and Parkinson's disease. Here, we review recent studies in mammals and Drosophila highlighting how nutrient- and stress-sensing in skeletal muscle can influence lifespan and overall aging of the organism. In addition to exercise and indirect effects of muscle metabolism, growing evidence suggests that muscle-derived growth factors and cytokines, known as myokines, modulate systemic physiology. Myokines may influence the progression of age-related diseases and contribute to the intertissue communication that underlies systemic aging.

KEYWORDS:

exercise; intertissue communication during aging; myokine signaling; skeletal muscle aging; systemic aging

PMID:
23802635
PMCID:
PMC3838468
DOI:
10.1111/acel.12126
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center