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Oncoimmunology. 2013 Mar 1;2(3):e23404.

Regulation of DC development and DC-mediated T-cell immunity via CISH.

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Department of Biological Sciences; Sungkyunkwan University; Suwon, Gyeonggi-do, South Korea ; Department of Physiology; Bangladesh Agricultural University; Mymensingh, Bangladesh.


Cytokine inducible SH2-containing protein (CISH) plays a crucial role in type 1 dendritic cell (DC) development as well as in the DC-mediated activation of cytotoxic T lymphocytes (CTLs). CISH expression at late DC developmental stages shuts down the proliferation of DC progenitors by negatively regulating signal transducer and activator of transcription 5 (STAT5) and facilitates the differentiation of DCs into potent stimulators of CTLs.


CISH; CTL activation; STAT5

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