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Oncoimmunology. 2013 Mar 1;2(3):e23304.

Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity.

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1
Institute of Immunology; University of Kiel; Kiel, Germany.

Abstract

The Vδ2 and non-Vδ2 (mainly Vδ1) subsets of human γδ T cells have distinct homing patterns and recognize different types of ligands, yet both exert potent antitumor effects. While the T-cell receptor of Vδ2 T cells primarily recognizes tumor cell-derived pyrophosphates, non-Vδ2 γδ T cells preferentially recognize stress-associated surface antigens. Here, we discuss the pros and cons of Vδ2 versus non-Vδ2 γδ T cells as tools for future immunotherapeutic interventions against cancer.

KEYWORDS:

Vδ1 T cells; Vδ2 T cells; cancer immunosurveillance; cytotoxicity; γδ T cells

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