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Int J Med Sci. 2013 Jun 14;10(8):988-94. doi: 10.7150/ijms.5944. Print 2013.

Lack of association of C-Met-N375S sequence variant with lung cancer susceptibility and prognosis.

Author information

1
1. Department of Chest Medicine, Chi Mei Medical Center, Tainan, Taiwan, ROC.

Abstract

BACKGROUND:

Previously, we identified a sequence variant (N375S) of c-Met gene, however, its association with lung cancer risk and prognosis remain undefined.

PATIENTS AND METHODS:

We investigated the genotype distribution of the c-Met-N375S sequence variant in 206 lung cancer patients and 207 non-cancer controls in the Taiwanese population by DNA sequencing.

RESULTS:

Lung cancer patients with variant A/G and G/G genotypes showed 1.08-fold increased cancer risk when compared to patients with the wild-type A/A genotype (95% CI, 0.60-1.91). There were no significant differences in postoperative survival between c-Met-N375S and wild-type patients. In the cell model, the c-Met-N375S cells showed a decrease in cell death upon treatment with MET inhibitor SU11274 compared to wild-type cells.

CONCLUSION:

Our data suggest that the c-Met-N375S sequence variant may not play a significant role in cancer susceptibility and the prognosis of lung cancer patients. The correlation with chemoresponse of c-Met-N375S is worth further investigation in patients receiving MET therapy.

KEYWORDS:

N375S; c-Met; cancer risk; lung cancer.; prognosis

PMID:
23801885
PMCID:
PMC3691797
DOI:
10.7150/ijms.5944
[Indexed for MEDLINE]
Free PMC Article

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