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Wiley Interdiscip Rev Dev Biol. 2012 Jan-Feb;1(1):114-37. doi: 10.1002/wdev.1. Epub 2011 Nov 28.

From genes to function: the C. elegans genetic toolbox.

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1
Department of Biology, Institut de Biologie de l'École Normale Supérieure, Paris, France. boulin@biologie.ens.fr

Abstract

This review aims to provide an overview of the technologies which make the nematode Caenorhabditis elegans an attractive genetic model system. We describe transgenesis techniques and forward and reverse genetic approaches to isolate mutants and clone genes. In addition, we discuss the new possibilities offered by genome engineering strategies and next-generation genome analysis tools.

PMID:
23801671
PMCID:
PMC3694748
DOI:
10.1002/wdev.1
[Indexed for MEDLINE]
Free PMC Article
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