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Curr Pain Headache Rep. 2013 Aug;17(8):355. doi: 10.1007/s11916-013-0355-6.

The role of vitamin D in pathophysiology and treatment of fibromyalgia.

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1
Department of Neurology and Neurosurgery, UNIFESP, Rua Botucatu 740, São Paulo, SP, Brazil, 04023-900. cjesus@superig.com.br

Abstract

Recent studies showed that most cells have receptors and enzymes responsible for metabolism of vitamin D. Several diseases have been linked to vitamin D deficiency, such as hypertension, diabetes, depression, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and chronic pain syndromes such as fibromyalgia. The association between fibromyalgia and vitamin D deficiency is very controversial in the literature with conflicting studies and methodological problems, which leads to more questions than answers. The purpose of this article is to raise questions about the association of hypovitaminosis D with fibromyalgia considering causal relationships, treatment, and pathophysiological explanations.

PMID:
23801008
DOI:
10.1007/s11916-013-0355-6
[Indexed for MEDLINE]
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