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Nat Rev Mol Cell Biol. 2013 Aug;14(8):475-88. doi: 10.1038/nrm3611. Epub 2013 Jun 26.

Diversifying microRNA sequence and function.

Author information

1
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, Austria. stefan.ameres@ imba.oeaw.ac.at

Abstract

MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only now beginning to understand how they are generated, assembled into functional complexes and destroyed. Various mechanisms have now been identified that regulate miRNA stability and that diversify miRNA sequences to create distinct isoforms. The production of different isoforms of individual miRNAs in specific cells and tissues may have broader implications for miRNA-mediated gene expression control. Rigorously testing the many discrepant models for how miRNAs function using quantitative biochemical measurements made in vivo and in vitro remains a major challenge for the future.

PMID:
23800994
DOI:
10.1038/nrm3611
[Indexed for MEDLINE]

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