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Nat Genet. 2013 Jul;45(7):720-1. doi: 10.1038/ng.2675.

Biological variability and the emergence of multidrug-resistant tuberculosis.

Abstract

A new study demonstrates that bacterial mutation rates associated with the Mycobacterium tuberculosis lineage most commonly linked to multidrug-resistant tuberculosis are multifold higher than shown in previous studies. This discovery, when considered together with recent findings on pharmacokinetic variability in patients, leads to new models of how multidrug-resistant tuberculosis arises, with direct therapeutic implications.

PMID:
23800865
DOI:
10.1038/ng.2675
[Indexed for MEDLINE]

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