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Nat Genet. 2013 Jul;45(7):717-8. doi: 10.1038/ng.2680.

Hypomethylation marks enhancers within transposable elements.

Abstract

Transposable elements (TEs) make up 50% of the human genome and are usually considered a mutational burden. A new study uses signatures of DNA hypomethylation to identify tissue-specific enhancers within TEs, providing fresh evidence that mobile DNA has a non-negligible role in genome regulation and evolution.

PMID:
23800863
DOI:
10.1038/ng.2680
[Indexed for MEDLINE]
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