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Chemosphere. 2013 Oct;93(6):1051-6. doi: 10.1016/j.chemosphere.2013.05.076. Epub 2013 Jun 22.

Antifungal efficacy of some natural phenolic compounds against significant pathogenic and toxinogenic filamentous fungi.

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Crop Research Institute, Drnovska 507, 161 06 Prague 6 Ruzyne, Czech Republic. Electronic address:


In terms of food safety, species of the Fusarium, Aspergillus and Penicillium genera are considered the most significant because they produce the great majority of known mycotoxins. Developing resistance against commonly used fungicides have become a critical problem in area such as agriculture, the storage and production of food and even in human medicines. The need for research and development of new alternative antifungal treatment based on natural antifungal substances is obvious. Here, the antifungal efficacy of 21 phenolic components of essential oils and plant substances were tested against these filamentous fungi with respect to their different molecular structures. Minimum inhibitory concentration values MIC₅₀ and MIC₁₀₀ were successfully estimated for 15 substances by means of probit analysis. Thymol and carvacrol were evaluated as the most effective. The MIC₅₀ values for thymol ranged from 30 to 52 μg mL(-1). The MIC₁₀₀ values for thymol ranged from 76 to 255 μg mL(-1), respectively. For carvacrol, the MIC₅₀ values ranged from 37 to 76 μg mL(-1), and the MIC100 ranged from 131 to 262 μg mL(-1). The results also revealed differences in the efficacy of phenols depending on molecular structures and different inter-species sensitivity.


Antifungal efficacy; Botanical fungicides; Essential oils; Molecular structure; Pathogenic fungi; Phenols

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