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J Stroke Cerebrovasc Dis. 2014 Feb;23(2):367-73. doi: 10.1016/j.jstrokecerebrovasdis.2013.05.025. Epub 2013 Jun 22.

The iScore predicts clinical response to tissue plasminogen activator in Korean stroke patients.

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Department of Neurology, Seoul Medical Center, Seoul, Korea.
Department of Neurology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
Department of Neurology, Soonchunhyang University Hospital, Seoul, Korea.
Department of Neurology, Yeungnam University Hospital, Daegu, Korea.
Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Korea.
Department of Neurology, Jeju National University Hospital, Jeju National University College of Medicine, Jeju, Korea.
Department of Neurology, Dongguk University Ilsan Hospital, Ilsan, Korea.
Department of Neurology, Ilsan Paik Hospital, Inje University, Ilsan, Korea.
Department of Neurology, Chonnam National University Hospital, Gwangju, Korea.
Department of Neurology, Dong-A University Hospital, Pusan, Korea.
Department of Neurology, Stroke Center, Seoul National University Bundang Hospital, Seongnam, Korea.
Department of Biostatistics, Korea University College of Medicine, Seoul, Korea.
Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Korea.
Department of Neurology, Seoul National University Hospital, Seoul, Korea.
Stroke Outcomes Research Centre, Division of Neurology, Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. Electronic address:



Despite substantial differences in clinical features between Asian and Western stroke patients, there are no published prognostic tools validated in an Asiatic population for thrombolytic therapy. We assessed the ability of the iScore to predict the clinical response after intravenous thrombolysis with tissue plasminogen activator (tPA) in a Korean stroke population.


We applied the iScore to eligible participants in the nationwide multicenter stroke registry in Korea. Main outcome measures were poor functional outcome defined as having a modified Rankin Scale score 3-6 and death at 3 months. Symptomatic intracranial hemorrhage (sICH) was evaluated as a safety outcome. C statistic was calculated to assess performance of iScore.


Among 4760 patients with an acute ischemic stroke, 622 (13.1%) received tPA, 548 patients had complete information for the analysis. C statistics for poor functional outcome and death at 3 months were .813 (95% confidence interval [CI]: .778-.848) and .820 (95% CI: .769-.872), respectively. Overall, there was a high correlation between observed and expected outcome for poor functional outcome (Pearson correlation coefficient, r = .982) and for death at 3 months (r = .950) at the risk score level. An iScore of 180 or more was associated with a more than 2 times risk of poor functional outcome and about 6 times risk of death at 3 months. There was an interaction between the iScore and tPA for a poor functional outcome (P value for the interaction < .001). We found a gradient effect in the incident risk of sICH with the iScore.


The iScore reliably predicts stroke outcomes after tPA in Asiatic population.


Risk score; ischemic stroke; prediction; thrombolysis

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