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J Neuroimmunol. 2013 Aug 15;261(1-2):134-40. doi: 10.1016/j.jneuroim.2013.05.014. Epub 2013 Jun 22.

Modulation of multiple sclerosis by sunlight exposure: role of cis-urocanic acid.

Author information

1
Department of Neurology, Institute for Neurological Research Dr. Raúl Carrea, FLENI, Buenos Aires, Argentina. jcorreale@fleni.org.ar

Abstract

The role of cis-urocanic acid (UCA) as a UV-mediated immunomodulator in MS patients was investigated. Plasma levels of cis-UCA were significantly lower in MS patients compared to controls. Stimulation of MBP- and MOG-specific T cells in the presence of cis-UCA, significantly increased IL-10, and inhibited IFN-γ production. PBMCs cultured in the presence of cis-UCA increased CD4(+)CD25(+)FoxP3(+) regulatory T cell percentages. Dendritic cells cultured in the presence of cis-UCA significantly reduced Ag presentation capacity. Finally, cis-UCA activated the 5-HT2A receptor, inducing the increase in phosphorylated forms of ERK 1/2 and JNK2. Thus, in addition to vitamin D, cis-UCA also appears to be an additional UV-mediated immunomodulator.

KEYWORDS:

Cytokines; Environmental factors; Multiple sclerosis; Ultraviolet radiation; Urocanic acid

PMID:
23800457
DOI:
10.1016/j.jneuroim.2013.05.014
[Indexed for MEDLINE]

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