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J Obstet Gynaecol Res. 2013 Aug;39(8):1354-8. doi: 10.1111/jog.12062. Epub 2013 Jun 26.

Recurrent cervical cancer in a patient who was compound heterozygous for UGT1A1*6 and UGT1A1*28 presenting with serious adverse events during irinotecan hydrochloride/nedaplatin therapy.

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  • 1Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Morioka, Japan.

Abstract

There have been no case reports of the risk of serious adverse events associated with the administration of irinotecan hydrochloride (CPT-11) in patients with gynecologic cancer who are compound heterozygous for UGT1A1*6 and UGT1A1*28. A 71-year-old patient presented with recurrent stage IIIb cervical cancer. Combined chemotherapy was initiated with CPT-11 (60 mg/m² on days 1 and 8) plus nedaplatin (NDP; 80 mg/m² on day 1), with each cycle lasting for 28 days. The patient was a compound heterozygote for UGT1A1*6 and UGT1A1*28. Hematotoxic adverse events observed during the chemotherapy were grade 4 neutropenia, grade 3 anemia, and grade 4 thrombocytopenia, and the non-hematotoxic adverse events were grade 3 diarrhea and grade 3 fatigue. The findings in this patient indicate that CPT-11 should be administered with great care, even at a dose of 60 mg/m², in patients receiving combined therapy with CPT-11 and NDP who are compound heterozygous for UGT1A1*6 and UGT1A1*28.

KEYWORDS:

UGT1A1*28; UGT1A1*6; adverse events; cervical cancer; irinotecan hydrochloride

PMID:
23800356
DOI:
10.1111/jog.12062
[PubMed - indexed for MEDLINE]
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