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J Hematol Oncol. 2013 Jun 24;6:42. doi: 10.1186/1756-8722-6-42.

Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology.

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1
Department of Laboratory Medicine, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno 656 53, Czech Republic.

Abstract

With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers.

PMID:
23800319
PMCID:
PMC3694472
DOI:
10.1186/1756-8722-6-42
[Indexed for MEDLINE]
Free PMC Article
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