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Exp Dermatol. 2013 Jul;22(7):505-6. doi: 10.1111/exd.12180.

Turning acne on/off via mTORC1.

Author information

1
Department of Surgery, Section of Dermatology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. billd860@gmail.com

Abstract

Over the past 10 years, the increase in comprehension of the mechanisms behind acne has been truly exponential. Starting with the ethnological work of Cordain, accelerated by the epidemiological work of Adebamowo, supported by the clinical trials of Smith and Mann, Kwon, DiLandro and others, the interface of diet and acne is coming into focus. Melnik now presents an exceptional pair of papers that illustrate for dermatologists what translational research is all about. The Western diet, the role of dairy, FoxO1 and mTORC1, the interplay of agonists and antagonists, therapeutics present and future - the jigsaw puzzle is coming together.

PMID:
23800069
PMCID:
PMC3746129
DOI:
10.1111/exd.12180
[Indexed for MEDLINE]
Free PMC Article

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