Format

Send to

Choose Destination
See comment in PubMed Commons below
Wiley Interdiscip Rev Dev Biol. 2013 May-Jun;2(3):301-26. doi: 10.1002/wdev.82. Epub 2012 Jul 23.

The history and enduring contributions of planarians to the study of animal regeneration.

Author information

1
Howard Hughes Medical Institute and Stowers Institute for Medical Research, Kansas City, MO, USA. asa@stowers.org

Abstract

Having an almost unlimited capacity to regenerate tissues lost to age and injury, planarians have long fascinated naturalists. In the Western hemisphere alone, their documented history spans more than 200 years. Planarians were described in the early 19th century as being 'immortal under the edge of the knife', and initial investigation of these remarkable animals was significantly influenced by studies of regeneration in other organisms and from the flourishing field of experimental embryology in the late 19th and early 20th centuries. This review strives to place the study of planarian regeneration into a broader historical context by focusing on the significance and evolution of knowledge in this field. It also synthesizes our current molecular understanding of the mechanisms of planarian regeneration uncovered since this animal's relatively recent entrance into the molecular-genetic age.

PMID:
23799578
PMCID:
PMC3694279
DOI:
10.1002/wdev.82
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center