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Pediatr Infect Dis J. 2013 Nov;32(11):1257-60. doi: 10.1097/INF.0b013e3182a09b6a.

Immune responses in infants whose mothers received Tdap vaccine during pregnancy.

Author information

1
From the *Dartmouth-Hitchcock Medical Center, Lebanon, NH; †University of Iowa Hospitals and Clinics, Iowa City, IA; ‡Geisel School of Medicine at Dartmouth, Hanover, NH; §Sanofi Pasteur, Swiftwater, PA; ¶Vanderbilt University School of Medicine, Nashville, TN; ‖University of Pittsburgh School of Medicine, Pittsburgh, PA; and **Cohen Children's Medical Center of New York, New Hyde Park, NY.

Abstract

BACKGROUND:

The effect of maternal Tdap vaccination on infant immunologic responses to routine pediatric vaccines is unknown.

METHODS:

This was a cohort study of infants whose mothers received or did not receive Tdap vaccine during pregnancy. Maternal and cord blood samples were collected at delivery; infant blood samples were collected before and after primary series and booster dose of diphtheria, tetanus, and acellular pertussis (DTaP) and other vaccines. Geometric mean antibody concentrations or titers to pertussis, hepatitis B, tetanus, diphtheria, Haemophilus influenzae type b and polio antigens were measured. Mean maternal-to-cord blood antibody ratios were calculated.

RESULTS:

At delivery, maternal and cord antibody concentrations to pertussis antigens were higher in the Tdap group (n=16) than control group (n=54; maternal: 1.9- to 20.4-fold greater; cord: 2.7- to 35.5-fold greater). Increased antibody concentrations persisted for infants at first DTaP (3.2- to 22.8-fold greater). After primary series, antibody concentrations to pertussis antigens were lower in Tdap group (0.7- to 0.8-fold lower), except for fimbriae types 2 and 3 (FIM) (1.5-fold greater). Antibody concentrations to pertussis antigens before and after booster dose were comparable (prebooster: Tdap group 1.0- to 1.2-fold higher than controls; postbooster: 0.9- to 1.0-fold lower). Differences in FIM values at these time points are difficult to interpret, due to varying FIM content among DTaP vaccines administered to infants in both groups.

CONCLUSIONS:

Maternal Tdap immunization resulted in higher pertussis antibody concentrations during the period between birth and the first vaccine dose. Although slightly decreased immune responses following the primary series were seen compared with controls, differences did not persist following the booster.

PMID:
23799518
DOI:
10.1097/INF.0b013e3182a09b6a
[Indexed for MEDLINE]

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