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PLoS One. 2013 Jun 17;8(6):e62906. doi: 10.1371/journal.pone.0062906. Print 2013.

The open access malaria box: a drug discovery catalyst for neglected diseases.

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1
Medicines for Malaria Venture (MMV), Geneva, Switzerland. spangenbergt@mmv.org

Abstract

Historically, one of the key problems in neglected disease drug discovery has been identifying new and interesting chemotypes. Phenotypic screening of the malaria parasite, Plasmodium falciparum has yielded almost 30,000 submicromolar hits in recent years. To make this collection more accessible, a collection of 400 chemotypes has been assembled, termed the Malaria Box. Half of these compounds were selected based on their drug-like properties and the others as molecular probes. These can now be requested as a pharmacological test set by malaria biologists, but importantly by groups working on related parasites, as part of a program to make both data and compounds readily available. In this paper, the analysis and selection methodology and characteristics of the compounds are described.

PMID:
23798988
PMCID:
PMC3684613
DOI:
10.1371/journal.pone.0062906
[Indexed for MEDLINE]
Free PMC Article
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