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J Oral Maxillofac Pathol. 2013 Jan;17(1):101-5. doi: 10.4103/0973-029X.110692.

Primary clear cell carcinoma of parotid gland: Case report and review of literature.

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Department of Oral and Maxillofacial Surgery, Marqués De Valdecilla University Hospital, Avda Valdecilla, Santander, Spain.


Clear cell carcinoma (CCC) is a rare low-grade carcinoma that represents only 1% to 2% of all salivary glands tumors. The finding of a clear cell tumor in a parotid gland involves the necessity of differential diagnosis between primary clear cell parotid tumors and metastases, mainly from kidney. The biological behavior is not very aggressive and development, which is very slow, is usually asymptomatic and indeed, the tumor often reaches considerable dimensions before being diagnosed. The treatment of choice is the surgical excision. There are rare cases of local recurrence and distant metastases. The aim of this article is to report a primary CCC in the parotid gland that microscopically closely resembled a metastatic CCC of renal origin, making microscopic differentiation difficult.


Clear cell carcinoma; parotid gland; primary parotid tumors; renal cell carcinoma

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