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J Cell Biol. 2013 Jun 24;201(7):969-79. doi: 10.1083/jcb.201212130.

Imaging cell biology in live animals: ready for prime time.

Author information

1
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. weigertr@mail.nih.gov

Abstract

Time-lapse fluorescence microscopy is one of the main tools used to image subcellular structures in living cells. Yet for decades it has been applied primarily to in vitro model systems. Thanks to the most recent advancements in intravital microscopy, this approach has finally been extended to live rodents. This represents a major breakthrough that will provide unprecedented new opportunities to study mammalian cell biology in vivo and has already provided new insight in the fields of neurobiology, immunology, and cancer biology.

PMID:
23798727
PMCID:
PMC3691462
DOI:
10.1083/jcb.201212130
[Indexed for MEDLINE]
Free PMC Article

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