Format

Send to

Choose Destination
See comment in PubMed Commons below
J Tissue Eng Regen Med. 2015 Apr;9(4):325-31. doi: 10.1002/term.1779. Epub 2013 Jun 24.

Research with parthenogenetic stem cells will help decide whether a safer clinical use is possible.

Author information

1
Centro de Biotecnología Animal - SERIDA, La Olla - Deva, Gijón, Asturias, Spain.

Abstract

The derivation and use of parthenogenetic stem cells (pESCs) are envisaged as a reliable alternative to conventional embryonic stem cells. Similar to embryonic stem cells in their proliferation, expression of pluripotency markers and capacity to multilineage differentiation, pESCs are at a lower risk of immune rejection within stem cell-based therapeutics. Moreover, pESCs represent an important model system to study the effect of paternally imprinted genes on cell differentiation. However, currently available information about the genetic and epigenetic behaviour of pESCs is limited. Thus, a detailed look at the biology of parthenogenetic (PG) embryos and PG-derived cell lines would allow gaining insight into the full potential of pESC in biotechnology. In this commentary article we review some features related to the biology of PG embryos and pESCs. In addition, novel traits on bovine pESCs (bpESCs) are discussed.

KEYWORDS:

Stem cells; X chromosome; bovine; in vitro; parthenote; preimplantation development

PMID:
23798507
DOI:
10.1002/term.1779
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center