Format

Send to

Choose Destination
See comment in PubMed Commons below
EMBO Rep. 2013 Aug;14(8):718-25. doi: 10.1038/embor.2013.88. Epub 2013 Jun 25.

Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling.

Author information

1
Department of Developmental and Regenerative Biology, New York, New York 10029, USA.

Erratum in

  • EMBO Rep. 2013 Sep;14(9):845.

Abstract

Wnt/β-catenin signalling is central to development and its regulation is essential in preventing cancer. Using phosphorylation of Dishevelled as readout of pathway activation, we identified Drosophila Wnk kinase as a new regulator of canonical Wnt/β-catenin signalling. WNK kinases are known for regulating ion co-transporters associated with hypertension disorders. We demonstrate that wnk loss-of-function phenotypes resemble canonical Wnt pathway mutants, while Wnk overexpression causes gain-of-function canonical Wnt-signalling phenotypes. Importantly, knockdown of human WNK1 and WNK2 also results in decreased Wnt signalling in mammalian cell culture, suggesting that Wnk kinases have a conserved function in ensuring peak levels of canonical Wnt signalling.

Comment in

PMID:
23797875
PMCID:
PMC3736130
DOI:
10.1038/embor.2013.88
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Grant support

Publication types

MeSH terms

Substances

Grant support

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center