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EMBO Rep. 2013 Aug;14(8):704-10. doi: 10.1038/embor.2013.87. Epub 2013 Jun 25.

The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres.

Author information

  • 1Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, INF 581, D-69120 Heidelberg, Germany.

Erratum in

  • EMBO Rep. 2013 Sep;14(9):845.

Abstract

Constitutive heterochromatin is crucial for the integrity of chromosomes and genomic stability. Here, we show that the chromatin remodelling complex NoRC, known to silence a fraction of rRNA genes, also establishes a repressive heterochromatic structure at centromeres and telomeres, preserving the structural integrity of these repetitive loci. Knockdown of NoRC leads to relaxation of centromeric and telomeric heterochromatin, abnormalities in mitotic spindle assembly, impaired chromosome segregation and enhanced chromosomal instability. The results demonstrate that NoRC safeguards genomic stability by coordinating enzymatic activities that establish features of repressive chromatin at centromeric and telomeric regions, and this heterochromatic structure is required for sustaining genomic integrity.

PMID:
23797874
PMCID:
PMC3736129
DOI:
10.1038/embor.2013.87
[PubMed - indexed for MEDLINE]
Free PMC Article
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