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Molecules. 2013 Jun 24;18(7):7336-45. doi: 10.3390/molecules18077336.

Bioactive phenylpropanoid glycosides from Tabebuia avellanedae.

Author information

1
Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. suomaorong@163.com

Abstract

Three novel phenylpropanoid glycosides 2, 5, 6 were isolated from water extract of Tabebuia avellanedae, together with three known phenylpropanoid glycosides 1, 3, 4. All compounds were identified on the basis of spectroscopic analysis and chemical methods and, for known compounds, by comparison with published data. All isolated compounds showed strong antioxidant activity in the DPPH assay, and compound 5 give the highest antioxidant activity among all compounds, with an IC₅₀ of 0.12 µM. All compounds exhibited moderate inhibitory effect on cytochrome CYP3A4 enzyme.

PMID:
23797703
PMCID:
PMC6270160
DOI:
10.3390/molecules18077336
[Indexed for MEDLINE]
Free PMC Article

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