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Dig Dis. 2013;31(1):118-25. doi: 10.1159/000347206. Epub 2013 Jun 17.

Primary sclerosing cholangitis and cholangiocarcinoma: pathogenesis and modes of diagnostics.

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Collaborative Research Centre 841, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.


Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease caused by progressive inflammation of the intra- and extrahepatic bile duct system. PSC patients have an increased risk to develop hepatobiliary as well as extrahepatic malignancies. The goal of a surveillance strategy for hepatobiliary malignancy in these patients is the detection of early cancer which will allow a potentially curative therapy. Here, we focus on a conceptual review of the pathogenesis of cholangiocellular carcinoma and gallbladder cancer and we will discuss a rational approach for the surveillance of these malignancies in PSC patients.

[Indexed for MEDLINE]

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