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Curr Opin Cell Biol. 2013 Oct;25(5):627-32. doi: 10.1016/j.ceb.2013.05.008. Epub 2013 Jun 21.

Role of adhesion receptor trafficking in 3D cell migration.

Author information

1
Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, M13 9PT, UK.

Abstract

This review discusses recent advances in our understanding of adhesion receptor trafficking in vitro, and extrapolates them as far as what is currently possible towards an understanding of migration in three dimensions in vivo. Our specific focus is the mechanisms for endocytosis and recycling of the two major classes of cell-matrix adhesion receptors, integrins and syndecans. We review the signalling networks that are employed to regulate trafficking and conversely the effects of trafficking on signalling itself. We then define the contribution that this element of the migration process makes to processes such as wound healing and tumour invasion.

PMID:
23797030
PMCID:
PMC3759831
DOI:
10.1016/j.ceb.2013.05.008
[Indexed for MEDLINE]
Free PMC Article

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