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Curr Opin Cell Biol. 2013 Oct;25(5):613-8. doi: 10.1016/j.ceb.2013.05.006. Epub 2013 Jun 21.

Integrins in mechanotransduction.

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1
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, United States.

Abstract

Forces acting on cells govern many important regulatory events during development, normal physiology, and disease processes. Integrin-mediated adhesions, which transmit forces between the extracellular matrix and the actin cytoskeleton, play a central role in transducing effects of forces to regulate cell functions. Recent work has led to major insights into the molecular mechanisms by which these adhesions respond to forces to control cellular signaling pathways. We briefly summarize effects of forces on organs, tissues, and cells; and then discuss recent advances toward understanding molecular mechanisms.

PMID:
23797029
PMCID:
PMC3757118
DOI:
10.1016/j.ceb.2013.05.006
[Indexed for MEDLINE]
Free PMC Article
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