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Dermatology. 2013;226(3):253-9. doi: 10.1159/000349992. Epub 2013 Jun 18.

Dermatology life quality index and side effects after topical photodynamic therapy of actinic keratosis.

Author information

1
Department of Dermatology, University of Heidelberg, Heidelberg, Germany. patrick.gholam@med.uni-heidelberg.de

Abstract

BACKGROUND:

Photodynamic therapy (PDT) is an excellent treatment option for actinic keratosis. However the side effects lead to an impairment of the patients' quality of life.

OBJECTIVES:

To evaluate the impact of PDT on patients' quality of life and to determine the frequency and intensity of side effects over the course of 4 weeks post PDT.

PATIENTS AND METHODS:

22 patients with actinic keratosis in the face were included into this prospective study. Pain was measured using a visual analog scale immediately and 8 h after PDT. The Dermatology Life Quality Index (DLQI) was assessed at screening, after treatment as well as 2 and 4 weeks after PDT. The physician and patient evaluated the intensity of side effects during the treatment, 2 and 4 weeks post PDT. Additionally, the patient documented side effects daily from the 1st to the 14th day after PDT and on day 28 post PDT, using a diary.

RESULTS:

We observed a significant (p < 0.001) increase in the DLQI from 1.6 ± 1.7 prior to PDT to 7.3 ± 4.9 post PDT. The DLQI normalized in the following 4 weeks. Immediately and 8 h after PDT mean pain was 4.3 ± 2.5 and 2.3 ± 2.1. Side effects documented by the patients were erythema (100%), pain, burning, edema (90.9%), itching (86.4%), scaling (81.8%) and pustules (59.1%). No scar formation, hyper-/hypopigmentation or infections were observed.

CONCLUSION:

PDT has a significant temporary impact on patients' DLQI. Transitory side effects are common and show typical kinetics.

PMID:
23796769
DOI:
10.1159/000349992
[Indexed for MEDLINE]

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