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Org Lett. 2013 Jul 5;15(13):3456-9. doi: 10.1021/ol401495c. Epub 2013 Jun 24.

Pattern-based sensing of peptides and aminoglycosides with a single molecular probe.

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Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

Erratum in

  • Org Lett. 2013 Sep 6;15(17):4624.


A coumarin-based molecular probe can be used for the sensing of peptides and aminoglycoside antibiotics. The probe reacts with the primary amine group(s) of the analytes to give a mixture of covalent adducts with distinct colors. Each analyte gives rise to a characteristic UV-vis spectrum. A pattern-based analysis of the spectra allows identifying structurally related analytes. Furthermore, it is possible to obtain information about the quantity and the purity of the analytes.

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