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Adv Mater. 2013 Sep 6;25(33):4580-4. doi: 10.1002/adma.201301201. Epub 2013 Jun 24.

Fluorescent nanoparticle delivered dsRNA toward genetic control of insect pests.

Author information

1
Department of Entomology, China Agricultural University, 100193 Beijing, China.

Abstract

A fluorescent cationic core-shell nanoparticle efficiently enters into cells with high transfection efficacy. A FNP/CHT10-dsRNA complex is orally fed to insect pests and knocks down a midgut-specific chitinase gene of the Asian corn borer, which leads to death. This is the first report on the genetic control of insect pests through a non-viral gene delivery system to knock down key developmental gene expression.

KEYWORDS:

dsRNAi; fluorescence; gene carrier; insect; nanoparticle

PMID:
23794475
DOI:
10.1002/adma.201301201
[Indexed for MEDLINE]
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