Format

Send to

Choose Destination
Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7766-71. doi: 10.1002/anie.201302727. Epub 2013 Jun 21.

Rigid DNA beams for high-resolution single-molecule mechanics.

Author information

1
Physik Department, Walter Schottky Institute, Technische Universität München, Am Coulombwall 4a, 85748 Garching near Munich, Germany.

Abstract

Bridging the gap: Rigid DNA linkers (blue, see picture) between microspheres (green) for high-resolution single-molecule mechanical experiments were constructed using DNA origami. The resulting DNA helical bundles greatly reduce the noise generated in studies of conformation changes using optical tweezers and were applied to study small DNA secondary structures.

KEYWORDS:

DNA nanotechnology; DNA structures; biophysics; force spectroscopy; single-molecule experiments

PMID:
23794413
PMCID:
PMC3749440
DOI:
10.1002/anie.201302727
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center