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Reprod Sci. 2014 Feb;21(2):230-5. doi: 10.1177/1933719113493512. Epub 2013 Jun 21.

Differential regulation of brain-derived neurotrophic factor in term and preterm preeclampsia.

Author information

1
1Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune, Maharashtra, India.

Abstract

Our earlier studies in preeclampsia (PE) suggest a causal relationship between altered angiogenic factors and birth outcomes. Recent studies suggest that brain-derived neurotrophic factor (BDNF) can stimulate angiogenesis. The present study examines the levels of maternal and cord BDNF in women with PE (n = 106; full term [n = 60] and preterm [n = 46]) and normotensive women (n = 95; control) delivering at term. Maternal BDNF levels were lower (P < .05) in women with PE when compared to normotensive women. Cord BDNF levels were higher (P < .01) in women with PE delivering at term, while it was lower (P < .01) in women delivering preterm. Maternal BDNF levels were negatively associated with systolic and diastolic blood pressure (P < .01 for both). Our data for the first time suggest a possible role for BDNF in the pathophysiology of PE. Differential regulation of cord BDNF levels in preterm PE suggests a need to follow-up children to assess the neurodevelopmental effects in later life.

KEYWORDS:

blood pressure; brain-derived neurotrophic factor; hypertension; preeclampsia

PMID:
23793470
DOI:
10.1177/1933719113493512
[Indexed for MEDLINE]

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