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Viruses. 2013 Jun 21;5(6):1571-86. doi: 10.3390/v5061571.

Bromodomain proteins in HIV infection.

Author information

1
Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA.

Abstract

Bromodomains are conserved protein modules of ~110 amino acids that bind acetylated lysine residues in histone and non-histone proteins. Bromodomains are present in many chromatin-associated transcriptional regulators and have been linked to diverse aspects of the HIV life cycle, including transcription and integration. Here, we review the role of bromodomain-containing proteins in HIV infection. We begin with a focus on acetylated viral factors, followed by a discussion of structural and biological studies defining the involvement of bromodomain proteins in the HIV life cycle. We end with an overview of promising new studies of bromodomain inhibitory compounds for the treatment of HIV latency.

PMID:
23793227
PMCID:
PMC3717722
DOI:
10.3390/v5061571
[Indexed for MEDLINE]
Free PMC Article

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