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J Int Assoc Provid AIDS Care. 2015 Mar-Apr;14(2):148-55. doi: 10.1177/2325957413488195. Epub 2013 Jun 21.

Burden and Determinants of Severe Anemia among HIV-Infected Adults: Results from a Large Urban HIV Program in Tanzania, East Africa.

Author information

1
School of Medicine, Muhimbili University Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania Management and Development for Health, Tanzania makubi55@gmail.com.
2
Department of Nutrition, Harvard School of Public Health, USA.
3
Departments of Epidemiology and Biostatistics, Harvard School of Public Health, USA.
4
Management and Development for Health, Tanzania Northwestern University, Chicago, IL, USA.
5
School of Medicine, Muhimbili University Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania Management and Development for Health, Tanzania.
6
Management and Development for Health, Tanzania Department of Nutrition, Harvard School of Public Health, USA.

Abstract

BACKGROUND AND METHODS:

This cross-sectional study aimed at determining the prevalence and risk factors for severe anemia, severe microcytic anemia, and severe normocytic anemia among HIV-infected individuals aged >15 years. Univariate and multivariate analyses were performed to identify the risk factors for anemia.

RESULTS:

Data from 40 408 patients were analyzed, showing an overall prevalence of 22% for severe anemia. The risk of developing severe anemia increased by 49% among patients with a body mass index of <18.5 kg/m(2), by approximately 2-fold among patients with the World Health Organization (WHO) stage III, and by 3-fold among patients with WHO stage IV illness. Severe normocytic anemia was uniquely increased among patients aged ≥50 years, among those with chronic diarrhea and Kaposi's sarcoma, and those taking cotrimoxazole.

CONCLUSION:

There was a high prevalence of severe anemia among adults infected with HIV. Focused identification of anemia should be based on the hemoglobin and mean corpuscular volume measurements.

KEYWORDS:

HIV; adults; burden; determinants; severe anemia

PMID:
23792708
PMCID:
PMC5523957
DOI:
10.1177/2325957413488195
[Indexed for MEDLINE]
Free PMC Article

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