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Environ Toxicol Pharmacol. 2013 Sep;36(2):463-71. doi: 10.1016/j.etap.2013.05.012. Epub 2013 Jun 3.

Involvement of retinoic acid-induced peroxiredoxin 6 expression in recovery of noise-induced temporary hearing threshold shifts.

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Department of Otolaryngology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, Republic of Korea.


All-trans retinoic acid (ATRA) is reported to reduce hair cell loss and hearing deterioration caused by noise-induced hearing loss (NIHL). The present study investigates the involvement of peroxiredoxin 6 (Prdx 6) in ATRA-mediated protection of temporary threshold shift of hearing. Mice fed with ATRA before or after exposure to white noise showed a faster recovery than untreated controls within 1 week, with a concomitant increase of cochlear Prdx 6 expression. Treatment of mouse auditory cells with ATRA induced Prdx 6 expression. A putative retinoic acid (RA)-response element (RARE) was identified in a murine Prdx 6 promoter region. Prdx 6 promoter activities were elevated in wild-type reporter plasmid-transfected cells, whereas no significant change in activity was in those with RARE-disrupted mutant reporter. RA receptor α (RARα) functions as a transactivator of Prdx 6 gene expression. These findings suggest that ATRA-induced Prdx 6 expression may be associated with rapid recovery from temporary NIHL.


ATRA; All-trans retinoic acid; Cochlea; NIHL; Noise-induced temporary threshold shift; Peroxiredoxin 6; Prdx 6; RAR; RARE; Retinoic acid-response element; all trans retinoic acid; noise-induced hearing loss; peroxiredoxin 6; retinoic acid receptors; retinoic acid-response element

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