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J Am Soc Hypertens. 2013 Sep-Oct;7(5):353-62. doi: 10.1016/j.jash.2013.05.003. Epub 2013 Jun 20.

A multicenter study of neurocognition in children with hypertension: methods, challenges, and solutions.

Author information

1
Department of Pediatrics, University of Rochester, Rochester, NY. Electronic address: Marc_lande@urmc.rochester.edu.

Abstract

Hypertensive adults demonstrate decreased performance on neurocognitive testing compared with that of normotensive controls. There is now emerging, preliminary evidence that children with hypertension also manifest neurocognitive differences when compared with normotensive controls, findings postulated to potentially represent early signs of hypertensive target organ damage to the brain. However, reports in children to date have been limited to database and single-center studies. We have established an ongoing, prospective, multicenter study of neurocognition in children with primary hypertension. This article outlines the study methods, with particular attention to the unique challenges in this area of clinical research. We highlight aspects of the study design that are specifically designed as solutions to these challenges.

KEYWORDS:

Executive function; blood pressure; cognition; pediatric

PMID:
23792121
PMCID:
PMC3783545
DOI:
10.1016/j.jash.2013.05.003
[Indexed for MEDLINE]
Free PMC Article
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