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Cancer Lett. 2013 Oct 10;339(2):153-8. doi: 10.1016/j.canlet.2013.06.008. Epub 2013 Jun 18.

Regulation and function of pyruvate kinase M2 in cancer.

Author information

1
Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: weiweiyang@sibcb.ac.cn.

Abstract

Altered metabolism is fundamental to the growth and survival of cancer cells. Pyruvate kinase M2 (PKM2), a key enzyme in cancer metabolism, has been demonstrated to play a central role not only in metabolic reprogramming but also in direct regulation of gene expression and subsequent cell cycle progression. This review outlines the current understanding of PKM2 protein kinase activity and regulatory mechanisms underlying PKM2 expression, enzymatic activity, and nuclear localization, thus highlighting PKM2 as a potential therapeutic target.

KEYWORDS:

Gene expression; PKM2; The Warburg effect

PMID:
23791887
PMCID:
PMC3950276
DOI:
10.1016/j.canlet.2013.06.008
[Indexed for MEDLINE]
Free PMC Article

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