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Cell. 2013 Jun 20;153(7):1431-4. doi: 10.1016/j.cell.2013.05.044.

Guarding against collateral damage during chromatin transactions.

Author information

1
Chromosome Stability and Dynamics Group, Department of Disease Biology, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark. matthias.altmeyer@cpr.ku.dk

Abstract

Signal amplifications are vital for chromatin function, yet they also bear the risk of transforming into unrestrained, self-escalating, and potentially harmful responses. Examples of inbuilt limitations are emerging, revealing how chromatin transactions are confined within physiological boundaries.

PMID:
23791174
DOI:
10.1016/j.cell.2013.05.044
[Indexed for MEDLINE]
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