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Clin Nutr. 2014 Apr;33(2):322-9. doi: 10.1016/j.clnu.2013.05.013. Epub 2013 Jun 1.

Bovine colostrum improves intestinal function following formula-induced gut inflammation in preterm pigs.

Author information

1
National Veterinary Institute, Technical University of Denmark, DK-1870 Frederiksberg C, Denmark. Electronic address: acfst@vet.dtu.dk.
2
National Veterinary Institute, Technical University of Denmark, DK-1870 Frederiksberg C, Denmark. Electronic address: pmhh@vet.dtu.dk.
3
Department of Nutrition, Exercise and Sports, University of Copenhagen, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark. Electronic address: ttn@life.ku.dk.
4
The Medical Research Laboratories, Department of Clinical Medicine, Faculty of Health Sciences, Aarhus University, DK-Aarhus C, Denmark. Electronic address: mette.bjerre@ki.au.dk.
5
National Veterinary Institute, Technical University of Denmark, DK-1870 Frederiksberg C, Denmark. Electronic address: kesk@vet.dtu.dk.
6
National Veterinary Institute, Technical University of Denmark, DK-1870 Frederiksberg C, Denmark. Electronic address: mboy@vet.dtu.dk.
7
U.S. Department of Agriculture - Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: bstoll@bcm.tmc.edu.
8
Department of Large Animal Sciences/Veterinary Reproduction and Obstetrics, University of Copenhagen, DK-1958 Frederiksberg C, Denmark. Electronic address: mhs@life.ku.dk.
9
Department of Animal Science, Aarhus University, DK-8030 Tjele C, Denmark. Electronic address: bentborg.jensen@agrsci.dk.
10
Department of Nutrition, Exercise and Sports, University of Copenhagen, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark. Electronic address: psa@life.ku.dk.

Abstract

BACKGROUND & AIMS:

Only few hours of formula feeding may induce proinflammatory responses and predispose to necrotizing enterocolitis (NEC) in preterm pigs. We hypothesized that bovine colostrum, rich in bioactive factors, would improve intestinal function in preterm pigs following an initial exposure to formula feeding after some days of total parenteral nutrition (TPN).

METHODS:

After receiving TPN for 2 days, preterm pigs were fed formula (FORM, n = 14), bovine colostrum (COLOS, n = 6), or formula (6 h) followed by bovine colostrum (FCOLOS, n = 14). Intestinal lesions, function, and structure, abundance and location of bacteria, and inflammation markers were investigated.

RESULTS:

NEC severity and interleukins (IL)-1β and -8 protein concentrations were lower, while villus height, galactose absorption, and brush-border enzyme activities were increased in the distal small intestine in COLOS and FCOLOS pigs, relative to FORM pigs. Intestinal gene expression of serum amyloid A, IL-1β, -6 and -8, and bacterial abundance, correlated positively with NEC severity of the distal small intestine.

CONCLUSIONS:

Bovine colostrum restores intestinal function after initial formula-induced inflammation in preterm pigs. Further studies are required to test if bovine colostrum may also benefit preterm infants during the challenging transition from total parenteral nutrition to enteral nutrition, when human milk is unavailable.

KEYWORDS:

Animal model; Bovine colostrum; Inflammation; Necrotizing enterocolitis

PMID:
23791159
DOI:
10.1016/j.clnu.2013.05.013
[Indexed for MEDLINE]
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